Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery.

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery† †Electronic supplementary information (ESI) available: Synthesis detail and characterization of supramolecular nucleoside phospholipids; fabrication of supramolecular liposomes and conventional liposomes, including fabrication of DOX-loaded supramolecular liposomes and conventional liposomes; details of in vitro experiments, including in vitro cytotoxicity studies, intracellular drug release, examination of cell viability of MCF-7 cells, apoptosis analyses and western blotting analysis; details of in vivo experiments, including pharmacokinetic studies, in vivo biodistribution and tumor targeting capability in tumor-bearing mice and in vivo antitumor efficacy. See DOI: 10.1039/c5sc01188d

Surface Recognition and Complexations Between Synthetic Poly(ribo)nucleotides and Neutral Phospholipids and Their Implications in Lipofection

Thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. The divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

Surface Recognition and Complexations Between Synthetic Poly(ribo)nucleotides and Neutral Phospholipids and Their Implications in Lipofection

Thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. The divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

Ab initio and charge study of phospholipids in gas phase and solution

phospholipids are important for the biological lipid and are commonly used in biophysical studies.A quantumcalculation for two phospholipids Dipalmitoylphosphatidylethanolamine and dipalmitoylphosphatidic acidwere performed using the abinitio software. Geometry optimization structures were obtained at RHF level using3-21G, 6-31G*. These basis sets were used To understanding the effects of envir...

Phytosome- a Novel Approach for Herbal Drug Delivery

The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption. Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids based drug delivery system have been found promising for b...